Evaluation of renal function using ^<99m>Tc-MAG3 : comparison with Bubeck method and renal uptake method
نویسندگان
چکیده
منابع مشابه
99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function.
About 14 years have passed since Fritzberg et al. developed 99mTc-MAG3 in 1986. The biological properties of this radiopharmaceutical are somewhat different from radioiodine labeled hippurate: it exhibits higher protein binding, slower blood clearance, higher extraction efficiency by tubular cells and larger excretion into the bile than the latter. Nonetheless, it has been widely used as the ag...
متن کاملSynthesis, formulation and quality control of 99mTc-MAG3, as a renal tubular 99mTc-radiopharmaceutical kit [Persian]
Radionuclidic techniques may provide assessment of glomerular filtration rate (GFR) effective renal plasma flow (ERPF) or individual renal function. Several agents were available for determination of these parameters such as ¹³¹I-OIH (O-iodohippurate) and different derivatives of DADS (Diamidodisulfur). OIH has the disadvantage of imparting a relatively high absorbed radiation dose to the...
متن کاملAssessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy
BACKGROUND Renal scintigraphy using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) is widely used for the assessment of renal function in humans. However, the application of this method to animal models of renal disease is currently limited, especially in rodents. Here, we have applied 99mTc-MAG3 renal scintigraphy to a mouse model of unilateral ureteral obstruction (UUO) and evaluated its utility...
متن کاملEstimation of 99mTc-MAG3 clearance by single-sample methods and camera-based methods.
We compared single-sample methods, proposed by Russell et al. and Bubeck et al., and camera-based methods in calculating 99mTc-MAG3 clearance, and determined camera-based methods that provide estimates comparable to those measured by the Russell method. Twenty-one patients underwent 99mTc-MAG3 renal scintigraphy, and clearance was measured by the Russell method and Bubeck method. Various renogr...
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ژورنال
عنوان ژورنال: Japanese Journal of Radiological Technology
سال: 1997
ISSN: 0369-4305,1881-4883
DOI: 10.6009/jjrt.kj00001355939